Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression

Cells exposed to ER-stress undergo the Unfolded Protein Response (UPR) to avoid apoptosis, but may also activate autophagy. However, the signal for selection of one of these two protective responses is unknown. To clarify the key switch between autophagy and apoptosis, we examined the correlation of...

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Detalhes bibliográficos
Main Authors: Matsumoto, Hiroki, Miyazaki, Shuichi, Matsuyama, Satoshi, Takeda, Masayuki, Kawano, Makoto, Nakagawa, Hiroshi, Nishimura, Kazuhiko, Matsuo, Saburo
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798192/
https://ncbi.nlm.nih.gov/pubmed/24167719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20135033
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