Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells

Sirtuins (a class III histone deacetylase) have emerged as novel targets for cancer therapy. Salermide, a reverse amide compound that inhibits Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2), has been shown to induce apoptosis in human cancer cells. The mechanism underlying cellular apoptotic signalling by...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Guangbo, Su, Ling, Hao, Xuexi, Zhong, Ning, Zhong, Diansheng, Singhal, Sunil, Liu, Xiangguo
Materialtyp: Artigo
Språk:Inglês
Publicerad: Blackwell Publishing Ltd 2012
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Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823229/
https://ncbi.nlm.nih.gov/pubmed/21801305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2011.01401.x
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