SREBP2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility

BACKGROUND: The molecular basis for the focal nature of atherosclerotic lesions is poorly understood. Here, we explored whether disturbed flow patterns activate an innate immune response to form the NLRP3 inflammasome scaffold in vascular endothelial cells (ECs) via sterol regulatory element binding...

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Detalhes bibliográficos
Main Authors: Xiao, Han, Lu, Min, Lin, Ting Yang, Chen, Zhen, Chen, Gang, Wang, Wei-Chi, Marin, Traci, Shentu, Tzu-pin, Wen, Liang, Gongol, Brendan, Sun, Wei, Liang, Xiao, Chen, Ju, Huang, Hsien-Da, Pedra, Joao H.F., Johnson, David A., Shyy, John Y-J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798034/
https://ncbi.nlm.nih.gov/pubmed/23838163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.002714
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