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Regulation of SIRT1 by Oxidative Stress-Responsive miRNAs and a Systematic Approach to Identify Its Role in the Endothelium

Significance: Oxidative stress is a common denominator of various risk factors contributing to endothelial dysfunction and vascular diseases. Accumulated evidence suggests that sirtuin 1 (SIRT1) expression and/or activity is impaired by supraphysiological levels of oxidative stress, which in turn di...

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Detalhes bibliográficos
Main Authors: Chen, Zhen, Shentu, Tzu-Pin, Wen, Liang, Johnson, David A., Shyy, John Y.-J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797452/
https://ncbi.nlm.nih.gov/pubmed/23477488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.4803
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