IL7Rα Expression and Upregulation by IFNβ in Dendritic Cell Subsets Is Haplotype-Dependent

The IL7Rα gene is unequivocally associated with susceptibility to multiple sclerosis (MS). Haplotype 2 (Hap 2) confers protection from MS, and T cells and dendritic cells (DCs) of Hap 2 exhibit reduced splicing of exon 6, resulting in production of relatively less soluble receptor, and potentially m...

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Autores principales: McKay, Fiona C., Hoe, Edwin, Parnell, Grant, Gatt, Prudence, Schibeci, Stephen D., Stewart, Graeme J., Booth, David R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797747/
https://ncbi.nlm.nih.gov/pubmed/24147013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077508
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