Distinct Tryptophan Catabolism and Th17/Treg Balance in HIV Progressors and Elite Controllers

Tryptophan (Trp) catabolism into immunosuppressive kynurenine (Kyn) by indoleamine 2,3-dioxygenase (IDO) was previously linked to Th17/Treg differentiation and immune activation. Here we examined Trp catabolism and its impact on Th17/Treg balance in uninfected healthy subjects (HS) and a large cohor...

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Bibliographic Details
Main Authors: Jenabian, Mohammad-Ali, Patel, Mital, Kema, Ido, Kanagaratham, Cynthia, Radzioch, Danuta, Thébault, Paméla, Lapointe, Réjean, Tremblay, Cécile, Gilmore, Norbert, Ancuta, Petronela, Routy, Jean-Pierre
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797729/
https://ncbi.nlm.nih.gov/pubmed/24147117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078146
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