Soluble CD40-ligand (sCD40L, sCD154) plays an immunosuppressive role via regulatory T cell expansion in HIV infection

CD40/CD40-ligand (CD40L) signalling is a key stimulatory pathway which triggers the tryptophan (Trp) catabolizing enzyme IDO in dendritic cells and is immunosuppressive in cancer. We reported IDO-induced Trp catabolism results in a T helper type 17 (Th17)/regulatory T cell (T(reg)) imbalance, and fa...

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Detalhes bibliográficos
Publicado no:Clin Exp Immunol
Main Authors: Jenabian, M-A, Patel, M, Kema, I, Vyboh, K, Kanagaratham, C, Radzioch, D, Thébault, P, Lapointe, R, Gilmore, N, Ancuta, P, Tremblay, C, Routy, J-P
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360200/
https://ncbi.nlm.nih.gov/pubmed/24924152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cei.12396
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