Enhanced SCAP Glycosylation by Inflammation Induces Macrophage Foam Cell Formation

Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) Cleavage-Activating Protein (SCAP) glycosylation plays crucial roles in regulating LDL receptor and 3-hydroxy-3-methyl-glutaryl-CoA redu...

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Detalhes bibliográficos
Main Authors: Zhou, Chao, Lei, Han, Chen, Yaxi, Liu, Qing, Li, Lung-Chih, Moorhead, John F., Varghese, Zac, Ruan, Xiong Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797718/
https://ncbi.nlm.nih.gov/pubmed/24146768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075650
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