Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice

Atherosclerosis is a serious age-related pathology, and one of its hallmarks is the presence of chronic inflammation. Sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) is a cholesterol sensor that plays an essential role in regulating intracellular cholesterol home...

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Bibliographic Details
Published in:Aging Dis
Main Authors: Li, Danyang, Liu, Mihua, Li, Zhe, Zheng, Guo, Chen, Amei, Zhao, Lei, Yang, Ping, Wei, Li, Chen, Yaxi, Ruan, Xiong Z.
Format: Artigo
Language:Inglês
Published: JKL International LLC 2021
Subjects:
Orginal Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8139202/
https://ncbi.nlm.nih.gov/pubmed/34094640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14336/AD.2020.1120
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