Enhanced SCAP Glycosylation by Inflammation Induces Macrophage Foam Cell Formation

Inflammatory stress promotes foam cell formation by disrupting LDL receptor feedback regulation in macrophages. Sterol Regulatory Element Binding Proteins (SREBPs) Cleavage-Activating Protein (SCAP) glycosylation plays crucial roles in regulating LDL receptor and 3-hydroxy-3-methyl-glutaryl-CoA redu...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhou, Chao, Lei, Han, Chen, Yaxi, Liu, Qing, Li, Lung-Chih, Moorhead, John F., Varghese, Zac, Ruan, Xiong Z.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797718/
https://ncbi.nlm.nih.gov/pubmed/24146768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075650
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