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Probing the Flexibility of Tropomyosin and Its Binding to Filamentous Actin Using Molecular Dynamics Simulations

Tropomyosin (Tm) is a coiled-coil protein that binds to filamentous actin (F-actin) and regulates its interactions with actin-binding proteins like myosin by moving between three positions on F-actin (the blocked, closed, and open positions). To elucidate the molecular details of Tm flexibility in r...

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Detalhes bibliográficos
Main Authors: Zheng, Wenjun, Barua, Bipasha, Hitchcock-DeGregori, Sarah E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797582/
https://ncbi.nlm.nih.gov/pubmed/24138864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.09.003
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