Tyrosine Kinase Signal Modulation: A Matter of H(2)O(2) Membrane Permeability?

H(2)O(2) produced by extracellular NADPH oxidases regulates tyrosine kinase signaling inhibiting phosphatases. How does it cross the membrane to reach its cytosolic targets? Silencing aquaporin-8 (AQP8), but not AQP3 or AQP4, inhibited H(2)O(2) entry into HeLa cells. Re-expression of AQP8 with silen...

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Main Authors: Bertolotti, Milena, Bestetti, Stefano, García-Manteiga, Jose M., Medraño-Fernandez, Iria, Dal Mas, Andrea, Malosio, Maria Luisa, Sitia, Roberto
Formáid: Artigo
Teanga:Inglês
Foilsithe: Mary Ann Liebert, Inc. 2013
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797449/
https://ncbi.nlm.nih.gov/pubmed/23541115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5330
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