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Pax6 Downregulation Mediates Abnormal Lineage Commitment of the Ocular Surface Epithelium in Aqueous-Deficient Dry Eye Disease

Keratinizing squamous metaplasia (SQM) of the ocular surface is a blinding consequence of systemic autoimmune disease and there is no cure. Ocular SQM is traditionally viewed as an adaptive tissue response during chronic keratoconjunctivitis sicca (KCS) that provokes pathological keratinization of t...

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Detalhes bibliográficos
Main Authors: Chen, Ying Ting, Chen, Feeling Y. T., Vijmasi, Trinka, Stephens, Denise N., Gallup, Marianne, McNamara, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797128/
https://ncbi.nlm.nih.gov/pubmed/24143217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077286
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