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PKCδ Localization at the Membrane Increases Matrix Traction Force Dependent on PLCγ1/EGFR Signaling

INTRODUCTION: During wound healing, fibroblasts initially migrate into the wound bed and later contract the matrix. Relevant mediators of transcellular contractility revealed by systems analyses are protein kinase c delta/myosin light chain-2 (PKCδ/MLC-2). PKCδ is activated by growth factor-driven P...

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Main Authors: Jamison, Joshua, Lauffenburger, Douglas, Wang, James C.-H., Wells, Alan
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796482/
https://ncbi.nlm.nih.gov/pubmed/24155954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077434
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