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Therapeutic dosing of FTY720 (Fingolimod) prevents cell infiltrate, rapidly suppresses ocular inflammation and maintains blood-ocular barrier

Fingolimod (FTY720) is a FDA-approved therapeutic, with efficacy demonstrated in experimental models of MS, and phase III human MS trials. FTY720 prevents T-cell migration to inflammatory sites, by down-regulating expression of the sphingosine-1 phosphate receptor normally required for egress from s...

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Detalhes bibliográficos
Main Authors: Copland, David A., Liu, Jian, Schewitz-Bowers, Lauren, Brinkmann, Volker, Anderson, Karen, Nicholson, Lindsay B., Dick, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796282/
https://ncbi.nlm.nih.gov/pubmed/22119714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.10.008
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