Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary glycoxidants precedes disease in adult humans; relevance to lifestyle-engendered chronic diseases

SIRT1 and PPARγ, host defenses regulating inflammation and metabolic functions, are suppressed under chronic high oxidant stress and inflammation (OS/ Infl) conditions. In diabetes, dietary advanced glycation end products (dAGEs) cause OS/Infl and suppress SIRT1. Herein, we ask whether dAGEs also su...

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Detalhes bibliográficos
Main Authors: Uribarri, Jaime, Cai, Weijing, Pyzik, Renata, Goodman, Susan, Chen, Xue, Zhu, Li, Ramdas, Maya, Striker, Gary E., Vlassara, Helen
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795943/
https://ncbi.nlm.nih.gov/pubmed/23636469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-013-1502-4
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