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N-Terminal Truncation of an Isolated Human IgG1 CH2 Domain Significantly Increases its Stability and Aggregation Resistance

Isolated human immunoglobulin G (IgG) CH2 domains are promising scaffolds for novel candidate therapeutics. Unlike other human IgG domains, CH2 is not involved in strong interchain interactions and isolated CH2 is relatively stable. However, isolated single CH2 is prone to aggregation. In native IgG...

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Detalhes bibliográficos
Main Authors: Gong, Rui, Wang, Yanping, Ying, Tianlei, Feng, Yang, Streaker, Emily, Prabakaran, Ponraj, Dimitrov, Dimiter S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795862/
https://ncbi.nlm.nih.gov/pubmed/23641816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400075f
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