Digitoflavone Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNFα through Downregulation of Expression of Nuclear Factor κB-Regulated Gene Products in Human Pancreatic Cancer Cells

Tumor necrosis factor-α (TNFα) activates both cell death and cell survival pathways. The activation of survival pathway renders most cancer cells resistant to TNF-induced cytotoxicity. We found that pretreatment with digitoflavone, a plant flavonoid, greatly sensitized TNFα-induced apoptotic cell de...

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Detalhes bibliográficos
Main Authors: Cai, Xueting, Lu, Wuguang, Yang, Yang, Yang, Jie, Ye, Juan, Gu, Zhenhua, Hu, Chunping, Wang, Xiaoning, Cao, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795624/
https://ncbi.nlm.nih.gov/pubmed/24146961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077126
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