USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

Lys63-linked polyubiquitination of transforming growth factor-β-activated kinase 1 (TAK1) has an important role in tumor necrosis factor-α (TNFα)-induced NF-κB activation. Using a functional genomic approach, we have identified ubiquitin-specific peptidase 4 (USP4) as a deubiquitinase for TAK1. USP4...

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Detalhes bibliográficos
Main Authors: Fan, Y-H, Yu, Y, Mao, R-F, Tan, X-J, Xu, G-F, Zhang, H, Lu, X-B, Fu, S-B, Yang, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136563/
https://ncbi.nlm.nih.gov/pubmed/21331078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.11
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