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Honokiol mediated inhibition of PI3K/mTOR pathway: A potential strategy to overcome immunoresistance in glioma, breast and prostate carcinoma without impacting T cell function

Inhibition of the PI3K/mTOR pathway is an appealing method for decreasing immunoresistance and augmenting T cell mediated immunotherapy. A major impediment to this strategy is the impact of conventional PI3K/mTOR pathway inhibitors on T cell function. In particular, Rapamycin, a well known immunosup...

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Main Authors: Crane, Courtney, Panner, Amith, Pieper, Russell O., Arbiser, Jack, Parsa, Andrew T.
格式: Artigo
語言:Inglês
出版: 2009
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795513/
https://ncbi.nlm.nih.gov/pubmed/19483651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181a8efe6
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