Substrate Inhibition of Uracil Phosphoribosyltransferase by Uracil Can Account for the Uracil Growth Sensitivity of Leishmania donovani Pyrimidine Auxotrophs

The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidine biosynthesis and salvage of pyrimidines from the host milieu. Genetic analysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enzyme not found in mammalian cells, as the focal enz...

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Bibliographic Details
Main Authors: Soysa, Radika, Wilson, Zachary N., Elferich, Johannes, Forquer, Isaac, Shinde, Ujwal, Riscoe, Michael K., Yates, Phillip A., Ullman, Buddy
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795293/
https://ncbi.nlm.nih.gov/pubmed/23986453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.478826
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