Ablation of Promyelocytic Leukemia Protein (PML) Re-patterns Energy Balance and Protects Mice from Obesity Induced by a Western Diet

The promyelocytic leukemia protein is a well known tumor suppressor, but its role in metabolism is largely unknown. Mice with a deletion in the gene for PML (KO mice) exhibit altered gene expression in liver, adipose tissue, and skeletal muscle, an accelerated rate of fatty acid metabolism, abnormal...

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Detalhes bibliográficos
Main Authors: Cheng, Xiwen, Guo, Shuang, Liu, Yu, Chu, Hao, Hakimi, Parvin, Berger, Nathan A., Hanson, Richard W., Kao, Hung-Ying
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795272/
https://ncbi.nlm.nih.gov/pubmed/23986437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.487595
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