Factor VIII C1 Domain Spikes 2092–2093 and 2158–2159 Comprise Regions That Modulate Cofactor Function and Cellular Uptake

The C1 domain of factor VIII (FVIII) has been implicated in binding to multiple constituents, including phospholipids, von Willebrand factor, and low-density lipoprotein receptor-related protein (LRP). We have previously described a human monoclonal antibody called KM33 that blocks these interaction...

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Bibliographic Details
Main Authors: Bloem, Esther, van den Biggelaar, Maartje, Wroblewska, Aleksandra, Voorberg, Jan, Faber, Johan H., Kjalke, Marianne, Stennicke, Henning R., Mertens, Koen, Meijer, Alexander B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795264/
https://ncbi.nlm.nih.gov/pubmed/24009077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.473116
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