Factor VIII Interacts with the Endocytic Receptor Low-density Lipoprotein Receptor-related Protein 1 via an Extended Surface Comprising “Hot-Spot” Lysine Residues

Lysine residues are implicated in driving the ligand binding to the LDL receptor family. However, it has remained unclear how specificity is regulated. Using coagulation factor VIII as a model ligand, we now study the contribution of individual lysine residues in the interaction with the largest mem...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: van den Biggelaar, Maartje, Madsen, Jesper J., Faber, Johan H., Zuurveld, Marleen G., van der Zwaan, Carmen, Olsen, Ole H., Stennicke, Henning R., Mertens, Koen, Meijer, Alexander B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505400/
https://ncbi.nlm.nih.gov/pubmed/25903134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.650911
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