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Centrosomal Protein DZIP1 Regulates Hedgehog Signaling by Promoting Cytoplasmic Retention of Transcription Factor GLI3 and Affecting Ciliogenesis

The primary cilium is required for Hedgehog signaling. So far, all known ciliogenic proteins regulate Hedgehog signaling through their role in ciliogenesis. Here we show that the mouse DZIP1 regulates Hedgehog signaling through two mechanisms. First, DZIP1 interacts with GLI3, a transcriptional regu...

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Bibliografiske detaljer
Main Authors: Wang, Chengbing, Low, Wee-Chuang, Liu, Aimin, Wang, Baolin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795250/
https://ncbi.nlm.nih.gov/pubmed/23955340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492066
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