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The decoupling of Smoothened from Gα(i) proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning
The Hedgehog (Hh) signal is transmitted by two receptor molecules, Patched (Ptc) and Smoothened (Smo). Ptc suppresses Smo activity, while Hh binds Ptc and alleviates the suppression, which results in activation of Hh targets. Smo is a seven-transmembrane protein with a long carboxyl terminal tail. V...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2597282/ https://ncbi.nlm.nih.gov/pubmed/18590719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2008.06.014 |
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