A Reducing Milieu Renders Cofilin Insensitive to Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Inhibition

Oxidative stress can lead to T cell hyporesponsiveness. A reducing micromilieu (e.g. provided by dendritic cells) can rescue T cells from such oxidant-induced dysfunction. However, the reducing effects on proteins leading to restored T cell activation remained unknown. One key molecule of T cell act...

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Détails bibliographiques
Auteurs principaux: Schulte, Bianca, John, Isabel, Simon, Bernd, Brockmann, Christoph, Oelmeier, Stefan A., Jahraus, Beate, Kirchgessner, Henning, Riplinger, Selina, Carlomagno, Teresa, Wabnitz, Guido H., Samstag, Yvonne
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795243/
https://ncbi.nlm.nih.gov/pubmed/24003227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.479766
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