Mitochondrial translocation of oxidized cofilin induces caspase-independent necrotic-like programmed cell death of T cells

Oxidative stress leads to T-cell hyporesponsiveness or death. The actin-binding protein cofilin is oxidized during oxidative stress, which provokes a stiff actin cytoskeleton and T-cell hyporesponsiveness. Here, we show that long-term oxidative stress leads to translocation of cofilin into the mitoc...

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Autors principals: Wabnitz, G H, Goursot, C, Jahraus, B, Kirchgessner, H, Hellwig, A, Klemke, M, Konstandin, M H, Samstag, Y
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032559/
https://ncbi.nlm.nih.gov/pubmed/21364663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.36
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