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A Biochemical Analysis Linking APOBEC3A to Disparate HIV-1 Restriction and Skin Cancer
Human deoxycytidine deaminase APOBEC3A (Apo3A) acts as an HIV-1 restriction factor in cells of myeloid lineage yet functions separately as a potent mutator for genomic DNA. Apo3A activity and C motif deamination specificity exhibit a striking dependence on pH that reflects these two distinct biologi...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3795231/ https://ncbi.nlm.nih.gov/pubmed/23979356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.504175 |
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