Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

The role of Type I interferon (IFN) during pathogenic HIV and SIV infections remains unclear, with conflicting observations suggesting protective versus immunopathological effects. We therefore examined the effect of IFNα/β on T cell death and viremia in HIV infection. Ex vivo analysis of eight pro-...

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Detalhes bibliográficos
Main Authors: Fraietta, Joseph A., Mueller, Yvonne M., Yang, Guibin, Boesteanu, Alina C., Gracias, Donald T., Do, Duc H., Hope, Jennifer L., Kathuria, Noshin, McGettigan, Shannon E., Lewis, Mark G., Giavedoni, Luis D., Jacobson, Jeffrey M., Katsikis, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795023/
https://ncbi.nlm.nih.gov/pubmed/24130482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003658
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