MicroRNA-155 controls CD8(+) T cell responses by regulating interferon signaling

We show that microRNA-155 (miR-155) is upregulated in primary effector and effector memory CD8(+) T cells but is low in naive and central memory cells. Anti-viral CD8(+) T cell responses and viral clearance were impaired in miR-155 deficient (miR-155-KO) mice, and this defect was intrinsic to CD8(+)...

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Detalhes bibliográficos
Main Authors: Gracias, Donald T., Stelekati, Erietta, Hope, Jennifer L., Boesteanu, Alina C., Doering, Travis, Norton, Jillian, Mueller, Yvonne M., Fraietta, Joseph A., Wherry, E. John, Turner, Martin, Katsikis, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664306/
https://ncbi.nlm.nih.gov/pubmed/23603793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2576
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