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Neurosteroid Analogues. 16. A new explanation for the lack of anesthetic effects of Δ(16)-alphaxalone and identification of a Δ(17(20)) analogue with potent anesthetic activity
This study addresses the hypothesis that the lack of anesthetic activity for (3α,5α)-3-hydroxypregn-16-ene-11,20-dione (Δ(16)-alphaxalone) is explained by the steroid Δ(16) double bond constraining the steroid 20-carbonyl group to a position that prevents it from favorably interacting with γ-aminobu...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3794474/ https://ncbi.nlm.nih.gov/pubmed/21504158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2002487 |
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