Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit()

Biosynthetically and chemically derived analogs of the antibiotic pactamycin and de-6-methylsalicylyl (MSA)-pactamycin have attracted recent interest as potential antiprotozoal and antitumor drugs. Here, we report a 3.1-Å crystal structure of de-6-MSA-pactamycin bound to its target site on the Therm...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tourigny, David S., Fernández, Israel S., Kelley, Ann C., Vakiti, Ramkrishna Reddy, Chattopadhyay, Amit Kumar, Dorich, Stéphane, Hanessian, Stephen, Ramakrishnan, V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2013
Pynciau:
Brevia
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794158/
https://ncbi.nlm.nih.gov/pubmed/23702293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.05.004
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