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Insights into translational termination from the structure of RF2 bound to the ribosome

The termination of protein synthesis occurs through specific recognition of a stop codon in the A site of the ribosome by a release factor (RF), which then catalyzes the hydrolysis of the nascent protein chain from the P-site tRNA. Here we present the crystal structure at 3.5 Å resolution of release...

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Detalhes bibliográficos
Main Authors: Weixlbaumer, Albert, Jin, Hong, Neubauer, Cajetan, Voorhees, Rebecca M., Petry, Sabine, Kelley, Ann C., Ramakrishnan, V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642913/
https://ncbi.nlm.nih.gov/pubmed/18988853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1164840
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