High-Throughput Screening (HTS) and Hit Validation to Identify Small Molecule Inhibitors with Activity against NS3/4A proteases from Multiple Hepatitis C Virus Genotypes

Development of drug-resistant mutations has been a major problem with all currently developed Hepatitis C Virus (HCV) NS3/4A inhibitors, including the two FDA approved drugs, significantly reducing the efficacy of these inhibitors. The high incidence of drug-resistance mutations and the limited util...

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Bibliografiska uppgifter
Huvudupphovsmän: Lee, Hyun, Zhu, Tian, Patel, Kavankumar, Zhang, Yan-Yan, Truong, Lena, Hevener, Kirk E., Gatuz, Joseph L., Subramanya, Gitanjali, Jeong, Hyun-Young, Uprichard, Susan L., Johnson, Michael E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793977/
https://ncbi.nlm.nih.gov/pubmed/24130685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075144
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