Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications

We previously developed two potent chemical classes that inhibit the essential papain‐like protease (PLpro) of severe acute respiratory syndrome coronavirus. In this study, we applied a novel approach to identify small fragments that act synergistically with these inhibitors. A fragment library was...

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Main Authors: Lee, Hyun, Cao, Shuyi, Hevener, Kirk E., Truong, Lena, Gatuz, Joseph L., Patel, Kavankumar, Ghosh, Arun K., Johnson, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado: WILEY‐VCH Verlag 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954986/
https://ncbi.nlm.nih.gov/pubmed/23788528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201300134
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