Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor

Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with alte...

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Bibliographic Details
Main Authors: Song, Xiulong, Chen, Yuan, Valanejad, Leila, Kaimal, Rajani, Yan, Bingfang, Stoner, Matthew, Deng, Ruitang
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793607/
https://ncbi.nlm.nih.gov/pubmed/24002920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M038323
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