Thromboxane A synthase-independent production of 12-hydroxyheptadecatrienoic acid, a BLT2 ligand

12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) has long been considered a by-product of thromboxane A(2) (TxA(2)) biosynthesis with no biological activity. Recently, we reported 12-HHT to be an endogenous ligand for BLT2, a low-affinity leukotriene B(4) receptor. To delineate the biosynthet...

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Bibliografiske detaljer
Main Authors: Matsunobu, Takehiko, Okuno, Toshiaki, Yokoyama, Chieko, Yokomizo, Takehiko
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2013
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793602/
https://ncbi.nlm.nih.gov/pubmed/24009185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M037754
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