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The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol
Proprotein convertase subtilisin/kexin type 9 (PCSK9) directly binds to the epidermal growth factor-like repeat A domain of low-density lipoprotein receptor and induces its degradation, thereby controlling circulating low-density lipoprotein cholesterol (LDL-C) concentration. Heterozygous loss-of-fu...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Dove Medical Press
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3793591/ https://ncbi.nlm.nih.gov/pubmed/24115837 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S36984 |
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