Epigenetic Priming of AML Blasts for All-trans Retinoic Acid-Induced Differentiation by the HDAC Class-I Selective Inhibitor Entinostat

All-trans retinoic acid (ATRA) has only limited single agent activity in AML without the PML-RARα fusion (non-M3 AML). In search of a sensitizing strategy to overcome this relative ATRA resistance, we investigated the potency of the HDAC class-I selective inhibitor entinostat in AML cell lines Kasum...

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Autors principals: Blagitko-Dorfs, Nadja, Jiang, Yi, Duque-Afonso, Jesús, Hiller, Jan, Yalcin, Arzu, Greve, Gabriele, Abdelkarim, Mahmoud, Hackanson, Björn, Lübbert, Michael
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792939/
https://ncbi.nlm.nih.gov/pubmed/24116031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075258
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