Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients

BACKGROUND: Mutations in the EZH2 gene are recurrently found in patients with myeloid neoplasms and are associated with a poor prognosis. We aimed to characterize genetic and epigenetic alterations of EZH2 in 58 patients (51 with acute myeloid leukemia and 7 with myelodysplastic or myeloproliferativ...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Stomper, Julia, Meier, Ruth, Ma, Tobias, Pfeifer, Dietmar, Ihorst, Gabriele, Blagitko-Dorfs, Nadja, Greve, Gabriele, Zimmer, Dennis, Platzbecker, Uwe, Hagemeijer, Anne, Schmitt-Gräff, Annette, Lübbert, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043064/
https://ncbi.nlm.nih.gov/pubmed/33845873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-021-01052-2
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