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Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients

BACKGROUND: Mutations in the EZH2 gene are recurrently found in patients with myeloid neoplasms and are associated with a poor prognosis. We aimed to characterize genetic and epigenetic alterations of EZH2 in 58 patients (51 with acute myeloid leukemia and 7 with myelodysplastic or myeloproliferativ...

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Bibliographische Detailangaben
Veröffentlicht in:	Clin Epigenetics
Hauptverfasser:	Stomper, Julia, Meier, Ruth, Ma, Tobias, Pfeifer, Dietmar, Ihorst, Gabriele, Blagitko-Dorfs, Nadja, Greve, Gabriele, Zimmer, Dennis, Platzbecker, Uwe, Hagemeijer, Anne, Schmitt-Gräff, Annette, Lübbert, Michael
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BioMed Central 2021
Schlagworte:	Research
Online Zugang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8043064/ https://ncbi.nlm.nih.gov/pubmed/33845873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-021-01052-2
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Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients

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