Deletion of the Sequence Encoding the Tail Domain of the Bone Morphogenetic Protein type 2 Receptor Reveals a Bone Morphogenetic Protein 7-Specific Gain of Function

The bone morphogenetic protein (BMP) type II receptor (BMPR2) has a long cytoplasmic tail domain whose function is incompletely elucidated. Mutations in the tail domain of BMPR2 are found in familial cases of pulmonary arterial hypertension. To investigate the role of the tail domain of BMPR2 in BMP...

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Detalhes bibliográficos
Main Authors: Leyton, Patricio A., Beppu, Hideyuki, Pappas, Alexandra, Martyn, Trejeeve M., Derwall, Matthias, Baron, David M., Galdos, Rita, Bloch, Donald B., Bloch, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3792867/
https://ncbi.nlm.nih.gov/pubmed/24116187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076947
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