Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency

OBJECTIVE: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and me...

Full description

Saved in:
Bibliographic Details
Published in:PLoS One
Main Authors: Malhotra, Rajeev, Burke, Megan F., Martyn, Trejeeve, Shakartzi, Hannah R., Thayer, Timothy E., O’Rourke, Caitlin, Li, Pingcheng, Derwall, Matthias, Spagnolli, Ester, Kolodziej, Starsha A., Hoeft, Konrad, Mayeur, Claire, Jiramongkolchai, Pawina, Kumar, Ravindra, Buys, Emmanuel S., Yu, Paul B., Bloch, Kenneth D., Bloch, Donald B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300181/
https://ncbi.nlm.nih.gov/pubmed/25603410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117098
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items