Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency

OBJECTIVE: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and me...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Malhotra, Rajeev, Burke, Megan F., Martyn, Trejeeve, Shakartzi, Hannah R., Thayer, Timothy E., O’Rourke, Caitlin, Li, Pingcheng, Derwall, Matthias, Spagnolli, Ester, Kolodziej, Starsha A., Hoeft, Konrad, Mayeur, Claire, Jiramongkolchai, Pawina, Kumar, Ravindra, Buys, Emmanuel S., Yu, Paul B., Bloch, Kenneth D., Bloch, Donald B.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300181/
https://ncbi.nlm.nih.gov/pubmed/25603410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117098
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