Inhibition of Bone Morphogenetic Protein Signal Transduction Prevents the Medial Vascular Calcification Associated with Matrix Gla Protein Deficiency

OBJECTIVE: Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and me...

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Pubblicato in:PLoS One
Autori principali: Malhotra, Rajeev, Burke, Megan F., Martyn, Trejeeve, Shakartzi, Hannah R., Thayer, Timothy E., O’Rourke, Caitlin, Li, Pingcheng, Derwall, Matthias, Spagnolli, Ester, Kolodziej, Starsha A., Hoeft, Konrad, Mayeur, Claire, Jiramongkolchai, Pawina, Kumar, Ravindra, Buys, Emmanuel S., Yu, Paul B., Bloch, Kenneth D., Bloch, Donald B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300181/
https://ncbi.nlm.nih.gov/pubmed/25603410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0117098
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