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Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking
Prion diseases encompass a diverse group of neurodegenerative conditions characterized by the accumulation of misfolded prion protein (PrP) isoforms. Other conformational variants of PrP have also been proposed to contribute to neurotoxicity in prion diseases, including misfolded intermediates as we...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3792687/ https://ncbi.nlm.nih.gov/pubmed/23771030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt276 |
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