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Mutant Telomere Sequences Lead to Impaired Chromosome Separation and a Unique Checkpoint Response

Mutation of the template region in the RNA component of telomerase can cause incorporation of mutant DNA sequences at telomeres. We made all 63 mutant sequence combinations at template positions 474–476 of the yeast telomerase RNA, TLC1. Mutants contained faithfully incorporated template mutations,...

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Detalhes bibliográficos
Main Authors: Lin, Jue, Smith, Dana L., Blackburn, Elizabeth H.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC379261/
https://ncbi.nlm.nih.gov/pubmed/14742705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E03-10-0740
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