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SERCA2a stimulation by istaroxime: a novel mechanism of action with translational implications
Sarcoplasmic reticular (SR) Ca(2+)-ATPase (SERCA2a) is central to cardiac electrophysiological and mechanical function. It ensures full diastolic relaxation minimizing delayed after-potentials that would otherwise compromise membrane electrophysiological stability, and optimizes SR Ca(2+) refilling...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Blackwell Publishing Ltd
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791988/ https://ncbi.nlm.nih.gov/pubmed/23822610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12288 |
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