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SERCA2a stimulation by istaroxime: a novel mechanism of action with translational implications

Sarcoplasmic reticular (SR) Ca(2+)-ATPase (SERCA2a) is central to cardiac electrophysiological and mechanical function. It ensures full diastolic relaxation minimizing delayed after-potentials that would otherwise compromise membrane electrophysiological stability, and optimizes SR Ca(2+) refilling...

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Detalhes bibliográficos
Autor principal: Huang, Christopher L H
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791988/
https://ncbi.nlm.nih.gov/pubmed/23822610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12288
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