Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure

OBJECTIVE: To verify whether a deficiency in the cardiac sarcoplasmic reticulum pump SERCA2a causes cardiac dysfunction in humans. DESIGN: Cardiac performance was measured in a serendipitous human model of primary SERCA2a deficiency, Darier's disease, an autosomal dominant skin disorder caused...

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Detalhes bibliográficos
Main Authors: Mayosi, B M, Kardos, A, Davies, C H, Gumedze, F, Hovnanian, A, Burge, S, Watkins, H
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2006
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1861003/
https://ncbi.nlm.nih.gov/pubmed/15845614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/hrt.2004.051037
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