SUMO1-dependent modulation of SERCA2a in heart failure

SR Ca(2+) ATPase 2a (SERCA2a) is a critical ATPase responsible for Ca(2+) re-uptake during excitation-contraction coupling. Impaired SR Ca(2+) uptake resulting from decreased expression and reduced activity of SERCA2a is a hallmark of heart failure (HF)(1). Accordingly, restoration of SERCA2a expres...

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Bibliographic Details
Main Authors: Kho, Changwon, Lee, Ahyoung, Jeong, Dongtak, Oh, Jae Gyun, Chaanine, Antoine H., Kizana, Eddy, Park, Woo Jin, Hajjar, Roger J.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443490/
https://ncbi.nlm.nih.gov/pubmed/21900893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10407
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