Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure

Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. We have previously described a role for the small ubiquitin-like modifier type 1 (SUMO-1) as a regulator of S...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kho, Changwon, Lee, Ahyoung, Jeong, Dongtak, Oh, Jae Gyun, Gorski, Przemek A., Fish, Kenneth, Sanchez, Roberto, DeVita, Robert J., Christensen, Geir, Dahl, Russell, Hajjar, Roger J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467461/
https://ncbi.nlm.nih.gov/pubmed/26068603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8229
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